6-APB

2023-10-12:

• Hamilton morris has an interview with Matt Baggot about his work on MDMA analogues like the APBs

6-ABP #

• David E. Nichols synthed it as a non-neurotoxic alternative to MDMA. There might not be any hangover at all.
• SNDRI (117, 150, 2698 nM Ki for NET, DAT, SERT respectively.)
• 5-HT2B full agonist.
  • Enter cardiotoxicity. Like it’s seriously strong there.
• High affinity for α2C.
• Benzo Fury(JACK)
• More sharp than MDMA

Dose #

• ~100-150 mg.
• Lasts 10+ hours until the comedown (unlike MDMA hich is more like 3-6) with a peak of ~4-6 hours.

Anecdotes #

• JC Denton recommends avoiding MDMA completely. 6-APB (from dnm) + 2-3 mg of 5-MeO-Mipt (aka Moxy) instead. Claims 6-APB is better in every single way than MDMA. This is roughly the borax combo, which is 5-MAPB + 5-MeO-MiPT + 2-FMA which is more like analogue/gray market alternative and less so safety as the priority
  • You wake up with basically no comedown (even on the combo). Maybe even an afterglow.
    • https://old.reddit.com/r/researchchemicals/comments/n3hs4a/6apb_5meomipt_combo_trip_report_this_is_amazing/
  • 5-MeO-MiPT is a psychedelic, but at low doses it’s euphoric and tactile and energizing.
  • Maybe with (PF)-deprenyl.
• 6-APB is better than MDMA
  • You get more control, whereas on MDMA (for better or worse in my opinion) it’s like you become a different person and say cringy (in retrospect!) things.
• https://bluelight.org/xf/threads/genuine-6-apb-vs-mda-or-mdma.657594/
  • *6-APB feels like MDMA in terms of euphoria, but lacks the overall empathic quality of MDMA. I find it easier to connect and open up to people on MDMA and there can be more of a speedy push with MDMA. *
  • Has more of a psychedelic edge to it; more introspective. It definitely has visuals beyond colors and whatnot.
  • Some people say they can’t tell them apart
• 6-APB has a little less empathy than MDMA, and the empathy also feels a lot less forced and more real, like the empathy you might experience on psychedelics (but of course a lot stronger). It’s not the lovey dovey hug mood you might know from MDMA, but a lot more theuraptic IME.
• A lot of people say pure MDMA, especially when taken in a more chill environment, can be deeply relaxing. Sedating even. 6-APB is more energetic.