5-HT6

links: reference: 10-4-2021

5-HT6 #

• Increases anxiety and memory deficits by decreasing Cholinergic function. So, antagonism is pro-social, enhances LTP and short term memory, and inhibits gabaergic neurotransmission.
• *5-Ht6 antagonism inhibits camp and disinhibits dopamine, norepinephrine, glutamate, and acetylcholine selectively in the pfc, without compromising striatal dopamine. Guanfacine shunts striatal dopamine into the pfc, and takes weeks to work with a really shitty adjustment period of low norepinephrine and blood pressure. Rosa rugosa works instantly without any apparent sides. *
• Antagonize with Rosa Rugosa/Mei Gui Hua.
  • HawaiiPharm has it: https://www.walmart.com/ip/Mei-Gui-Hua-Rosa-Rugosa-Dry-Bud-Liquid-Extract-Tincture-Expertly-Extracted-Trusted-HawaiiPharm-Brand-Absolutely-Natural-Proudly-made-USA-Tincture-2-F/2798524369 JC takes literally 2-3 drops and it lasts all day. Higher doses and the hyperfrontality turns to edginess. Also says it enhances sleep despite feeling excitatory. Gavin used literally 4-5mL tho, for daydreaming and increasing baseline brain activity/overstimulation. Distanced but present feeling in social contexts.
  • Chemical compounds, anti-aging and antibacterial properties of Rosa rugosa Purple branch