URB-597

2023-12-17:

URB-597 #

• Off-target inhibition of Tyrosine Hydroxylase phosphorylation via some obscure cannabinoid receptor.
  • The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB1- and FAAH-independent mechanisms
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      • Due to ERK1/ERK2 inhibition. Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain