TGR5

2023-08-31:

TGR5 #

AKA GPCR19 or GBPAR1 (GPC bile acid receptor 1). Indeed, its natural ligands are bile acids of all things. Activates Gαs and MAPK. Suppresses macrophage functions.

• Activates 5’-Deiodinase:
  • Olive Leaf Extract boosts concentration of active thyroid hormone
  • Bile acids heat things up
• Transmembrane G protein-coupled receptor 5 signaling stimulates fibroblast growth factor 21 expression concomitant with up-regulation of the transcription factor nuclear receptor Nr4a1