Superoxide Dismutase

2022-07-03: reference:

Superoxide Dismutase #

• Catalyzes partitioning of Superoxide into O2+H2O2. However, overexpression can cause cell damage via H2O2.
• Copper+Zinc dependent.
• Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons (2007)
  • (SOD-1) mutant astrocytes do not cause the death of spinal GABAergic or dorsal root ganglion neurons or of embryonic stem cell–derived interneurons.
  • In contrast to astrocytes, fibroblasts, microglia, cortical neurons and myocytes expressing mutated SOD1 do not cause overt neurotoxicity