Serotonin N-Acetlytransferase
2023-08-18:
Serotonin/Aralkylamine N-Acetyltransferase (AANAT) #
Catalyzes Serotonin → N-Acetylserotonin.
-
Protein kinase C regulates the activity and stability of serotonin N-acetyltransferase
- PKC Phosphorylates Ser/Thr residues that enhance the stability/enzymatic activity of AANAT.
- PKA also phosphorylates 2 key residues
- PKC Phosphorylates Ser/Thr residues that enhance the stability/enzymatic activity of AANAT.
-
Chronic fluoxetine administration increases the serotonin N-acetyltransferase messenger RNA content in rat hippocampus
- CREB → TrkB/BDNF
- CREB → AANAT