SNARE

2022-05-05: reference:

• Calcium Control of Neurotransmitter Release (2012)
• Molecular mechanisms of neurotransmitter release

SNARE #

• SNARE = SNAP REceptor = SNAP-25, syntaxin (t-SNARE?), Synaptobrevin. I think that’s it besides the subtypes; Synaptotagmin isn’t a SNARE proper and merely associates with the complex
  • SNAP-25 aka VAMP (vesicle-associated membrane protein) interesting how it depicts membrane constituents mixing as it progresses…
• The intitial sensor is Synaptotagmin, and it becomes activated after 4-5 Ca2+ bind:
• Syntaxin and SNAP-25 are the cell membrane. At the vesicle membrane, synaptobrevin and Synaptotagmin, which binds Ca2+.

• Omega-3 polyunsaturated fatty acids promote SNAREs mediated GLUT4 vesicle docking and fusion #