PDE4
2022-05-04: reference:
PDE4 #
- Rolipram, acting as an inhibitor of PDE4, was found to repair the imbalance in the CREB/BDNF/Arc pathway R
- Rolipram also increases executive function.
- Rolipram impairs Working Memory in aged monkeys (presumably via PDE4i):
Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline
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Age-Realted Memory Impairment - is the cure worse than the disease?
- Supranormal D1-induced overstimulation impairs working memory R, as does PFC PKA activation.
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Age-Realted Memory Impairment - is the cure worse than the disease?
- PDE4B inhibition: may be anti-nootropic
- PDE4D inhibition: maybe nausea