Mitochondrial Fission

2022-05-28: reference:

Mitochondrial Fission #

• Overall it’s what it sounds like. Mitochondria are constantly changing shape.
• One use of fusion is for genetic completion - if the two mitochondria have damaged genomes, they may overlp to encode what the other lacks.
• Regulated by Dynamin proteins, GTPases: Drp1, OPA1/Mgm1, and mitofusins (Mfn1, Mfn2).
• Insulin Resistance and Mitochondrial Dysfunction
  • Individuals with insulin resistance, both with established T2D and high-risk individuals, have consistently demonstrated a diverse array of defects in mitochondrial function (i.e., bioenergetics, biogenesis and dynamics
• [Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle]( https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22083962
  • Excess [Palmitic Acid], but not hyperglycemia, hyperinsulinemia, or elevated tumor necrosis factor alpha, induced mitochondrial fragmentation and increased mitochondrion-associated Drp1 and Fis1 in differentiated C2C12 muscle cells

• Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease #

• The turnbuckle protocol https://www.longecity.org/forum/topic/94224-manipulating-mitochondrial-dynamics/page-9 or https://old.reddit.com/r/Nootropics/comments/ohg85f/turnbuckle_longecity_mitochondrial_fissionfusion/ has 2 mini-stacks you take on alternate days for mitochondrial fission and fusion.