Interneuron

2022-04-09: reference:

Interneuron #

• Reductions in gabaergic inhibition reduce the activity of emotional regulation and processing of sensory information leading to “Disinhibition”

• Inhibitory GABAergic interneurons contribute to sensory gating, memory encoding, emotional processing, attention processes, etc.

• They can still express various enzymes. But so do regular neurons obviously - I think the only real distinction is their nonconnection to sensorimotor inputs.

• Not always inhibitory via GABA; can be inhibitory with glycine, or can be glutamateric or acetylcholinergic. But probably niche cases.

• Constrained brain volume in an efficient coding model explains the fraction of excitatory and inhibitory neurons in sensory cortices

  • Interesting way of putting it: EI-ratio.PNG

• Savants have very high levels of inhibition. More intelligent animals have a higer ratio of inhibitory neurons.

• Three Groups of Interneurons Account for Nearly 100% of Neocortical GABAergic Neurons

Physiology #

• There are technically, along with local interneurons, relay neurons - which do project from one brain area to another.