Human Equivalent Dose
2021-11-28 links: reference:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/
- http://clymer.altervista.org/minor/allometry.html
- Interpretation of Animal Dose and Human Equivalent Dose for Drug Development
?Human Equivalent Dose #
- HED = mg/kg / conversion factor (which is human km (standard=37)/animal km)
- Km = body weight $\div$ body surface area (me: ~1.9; use online calculator) = 39.2.
- i.e 50mg/kg x (6/39.2 = 0.15333) = 7.65mg/kg
- Km = body weight $\div$ body surface area (me: ~1.9; use online calculator) = 39.2.
- More like 6.5ish for me for rat
Freebasing #
- Conversion constant = HCL salt molecular weight / freebase molecular weight. The former is ~36.5 + the freebase molecule, so something like 1.12-1.14