Histamine Intolerance

links: Histamine reference: 4-19-2021

Histamine Intolerance #

Here’s what I’m thinking: I’m somewhat hypothyroid and eat low quality conventional animal products, which leads to high estrogen, which leads to higher levels serotonin and histamine, leading to SIBO, leading to Candida.

When the body fails to break down histamine; responsible are the enyzmes:

• DAO (in the digestive tract)
• Histamine N-metyhltransferase (HMT) (in the CNS).
  • Impaired methylation can cause a deficiency, naturally. B12, C, and iron are also important.

Symptoms include:

• Stomach pain
• Herat palpitations
• Diarrhea
• Dizziness
• Flushing
• Headache
• Insomnia
• Brain fog
• Blood pressure
• Puffy eyes (there are mast cells in the eyes; blood vessels in the eyes/eyelids swell due to histamine release)
• Airway constriction
• OCD

• Not mediated by IgE. Skin allergy testing would not apply for histamine intolerance.

• Histamine liberators are not high in histamine themselves, but promote its release. Citrus, pineapples, bananas, strawberry, cocoa, coffee, seafood, and egg whites, and fermented food are notable.

• There are 4 primary receptors that histamines bind to.

• H1 (immune system) can cause problems with skin, cardio, gastrointestinal, uterus, and respiratory system.

• H2 (stomach) is the same, but also bone marrow. Histamine contorts the function of hydrochloric acid.

• H3 (brain) can affect the CNS.

  • It is the auto-receptor; activating it lowers histamine, DA, GABA, noradrenaline, and acetylcholine.
    • https://men-elite.com/2020/01/03/the-high-dopamine-histamine-personality/
      • https://www.sciencedirect.com/science/article/pii/S0301008210001334?via%3Dihub

• H4 (bone marrow). Most allergy medications only block H1/H2. Antihistamines are pretty fucked up though.

• SIBO etc. can lead to a histamine intolerance.

  • SIBO-like symptom can be a sign of low histamine? https://raypeatforum.com/community/threads/anybody-here-really-cured-histamine-intolerance.38867/post-608381
    • In which case, zinc and acid secretions via histidine should be increased.

• Having too much zinc in your system (relative to copper, one would assume) can lead to a histamine intolerance: histamine and thyroid are inversely correlated. If not, one may be copper deficient.

  • But, zinc may increase cortisol which would help.

• Iodine inhibits histamine formation in very large doses.

• Calcium can reduce histamine stores.

• Folate can cause histadelia

• Vitamin C binds to histamine. Consider a vitamin C flush.

• Quercetin/ Bromelain combo + lemon bioflavinoids limits histamine release from mast cells. Take for 1-2 weeks; it’s another kind of flush for an acute histamine release bout.