Govadine

2023-12-19:

Govadine #

• A Tetrahydroprotoberberine (THPB).
• Prefrontal cortex mechanisms of the novel cognitive enhancer d-govadine
  • *demonstrated to significantly enhance working memory and behavioural flexibility in several prefrontal cortex (PFC)-dependent rodent tasks. d-GOV also has high, selective affinity for dopamine (DA) D1 receptors (D1DRs), and selectively potentiates DA efflux in the PFC. This unique pharmacology sets it apart from many dopaminergic drugs and likely contributes to its cognitive effects. However, it is unclear how d-GOV selectively elevates PFC DA or what the functional effects of d-GOV binding to D1DRs are in the PFC. *
• Potentiation of prefrontal cortex dopamine function by the novel cognitive enhancer d-govadine