GPR12
2022-08-12: reference:
GPR12 #
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Advances in Neurobiology and Pharmacology of GPR12
- GPR12 seems to be endogenously activated by the lysophospholipids Sphingosine-1-phosphate (S1P) and sphingosyl-phosphorylcholine (SPC) (possibly agonists). #Ankified
- Exogenously, GPR12 is a target for the phytocannabinoid CBD. (which is an inverse agonist)
- Functionally, GPR12 seems to be related to neurogenesis and neural inflammation, but its relationship with cognitive functions remains to be characterized.
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A Thalamic Orphan Receptor Drives Variability in Short-Term Memory
- We screened ~200 genetically diverse mice on a Working Memory task and identified a genetic locus on chromosome 5 that contributes to a substantial proportion (17%) of the phenotypic variance.
- Each DO mouse represents a unique mosaic of the parental strains and has a high degree of heterozygosity. They did quantitative trait loci (QTL) mapping, to find the ‘Smart1 locus’ (spontaneous T-maze alternation QTL 1). Then, Further examination of this (chromosome 5) locus, through gene-expression, loss of function, and behavioral studies, revealed a gene encoding an orphan G-protein-coupled receptor.
- We screened ~200 genetically diverse mice on a Working Memory task and identified a genetic locus on chromosome 5 that contributes to a substantial proportion (17%) of the phenotypic variance.
- Target with Nesfatin-1, endogenous hypothalamic peptide.