Flavonoid
2022-02-20 links: reference:
Flavonoid #
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Impact of flavonoids on thyroid function
- The first observation regarding their biological activities was made in the 1930s, when a compound obtained from lemon peel was shown to reduce capillary permeability by Rusznyak and Szent-Györgi.
- There are several proposed mechanisms of action to explain anti-inflammatory activity of flavonoids, including:
- Antioxidative and radical scavenging activities (via chleation of divalent ions)
- modulation of inflammation-related cells activity (mast cells, macrophages, lymphocytes, and neutrophils)
- Regulation of the enzymes involved in the metabolism of arachidonic acid (Phospholipase A2, COX, LOX) and nitric oxide synthase
- modulation of other proinflammatory molecules production
- proinflammatory gene expression regulation
- Flavonoids function as pigments important for defense and development.
- Goiter was seen in infants sold Soy formula.