Enkephalin

2022-03-02: reference:

Enkephalin #

Neuropeptide which binds to δ-Opioid Receptors and μ-Opioid Receptors.

Dopamine #

• Inhibits Tyrosine Hydroxylase in the Tuberoinfundibular Pathway R
• Pro-D2:
  • Dopamine receptor gene expression by enkephalin neurons in rat forebrain
    • Mu opioid receptor involvement in enkephalin activation of dopamine neurons in the ventral tegmental area μ-Opioid Receptor, perhaps the μ-1 isoreceptor - mediates a portion of the activation of A10 dopamine neurons previously demonstrated with mixed mu and delta opioid agonists.
• Enkephalin modulation of A10 dopamine neurons: a role in dopamine sensitization (1988)
  • Microinjection of enkephalin analogues into the A10 region of rats produces an increase in spontaneous motor activity - associated with increased DA metabolism in the nucleus accumbens
  • Iontophresis of opioids was found to facilitate the spontaneous activity of DA neurons, but was inhibitory on spontaneously active non-DA neurons.