Dendrite

2022-12-20:

• Branching mechanisms shaping dendrite architecture

Dendrite #

• this is a progression of maturity, with the “occasional” branched spine.
• Basal (shorter, more radially distributed) and basically branch out of the soma area. vs apical (more distal)
• Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
  • There are a few types of dendritic spines, like mushroom spines, where AMPAR is rich. Pretty much linear relationship between spine volume and current from glutamate, and something of an inverse relationship between volume and length:
• Decreasing the neck radius increases the force necessary to transport recycling endosomes through the actin rich constriction, and increases the retention of receptors at the synapse R
• Dendritic spine dysgenesis in autism related disorders
  • (compare )
• Of Mice and Men: Increased dendritic complexity gives rise to unique human networks (Sep 2023)
  • We next show that topological complexity leads to highly interconnected pyramidal-to-pyramidal and higher-order networks, which is unexpected in view of reduced neuronal density in humans compared to mouse neocortex