Ampakine

2022-05-12: Nootropics reference:

Ampakines #

• Ampakines either enhance binding (high impact), or slows receptor sensensitization, enhances current, etc. (low impact). The latter prevents desensitization.
  • High impact ampakines induce BDNF without glutamate, which essentially means they’re agonists.
• Cogmetics says a short half-life (and potent) ampakine would be best.
• AMPA Receptor Positive Allosteric Modulators Attenuate Opioid Tolerance and Dependence

CX-1739 #

Related to CX717: but has 3-5x the potency. A bona fide ampakine, many of which are developed by RespireRx which has other CX- compounds. As such I might as well alias this note as ampakine. Safe and everything but inconclusive trials; in development.