Alirinetide

2023-11-22:

Alirinetide #

• 6 amino acid peptide (H-Phe-Ser-Arg-Tyr-Ala-Arg-OH)
• GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis
  • We identified 2867 protein-coding genes with expression significantly altered by GM6
  • GM6 further down-regulated the expression of genes associated with mitochondria, inflammatory responses, mRNA processing and chromatin organization. GM6-increased genes were located near GC-rich motifs interacting with C2H2 zinc finger transcription factors, whereas GM6-decreased genes were located near AT-rich motifs associated with helix-turn-helix homeodomain factors
    • STAT3, HOXD11 , HES7, GLI1. ECM modulation, activation of Notch and Hedgehog.
• GM604 down-regulates SOD1 and alters expression of 89 genes associated with amyotrophic lateral sclerosis