Aconitase

2022-06-29: reference:

• Itaconate or how I learned to stop avoiding the study of immunometabolism (idk where else to put this). Itaconate is made by diverting aconitate away from TCA during inflammatory macrophage activation

Aconitase #

• Part of TCA.
• Citrate -> cis-aconitate-> Isocitrate.
• Aconitase activity is severely depleted in the brains of patients with certain severe neurological disorders such as Huntington’s disease