ADAM12

2022-06-28: reference:

ADAM12 (a disintegrin and Metalloproteinase) #

(It’s bad)

• ADAM12 is expressed by astrocytes during experimental demyelination
  • Almost exclusively expressed in Oligodendrocytes, but if they are lost, astrocytes are the main source.
  • Exposure to inflammation (LPS/TNF/H2O2 etc.) regulates its expression.
• Biography: From putative brain tumor marker to high cognitive abilities: emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain
• A genome-wide association study for extremely high intelligence
• Interacts with alpha-actinin-2, IGFBP-3, and PI3K regulatory subunit 1.
• ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3 (S = secreted/soluble)
• ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function
• ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway
  • (EMT = epithelial to mesenchymal transition)