ACD856

2023-12-19:

ACD856 #

Trk Receptor pan PAM. Especially TrkC.

• ACD855 (Ponazuril) is also a thing, which is biased more towards TrkB.
  • Was reported to be anti-nootropic apparently? People got their hands on it??
• ACD856: A novel positive allosteric modulator of Trk-signaling in clinical development for the treatment of Alzheimer’s disease
• ACD856 binds directly to the TrkA receptor to increase the number of catalytic cycles per timepoint. This mechanism of action is a probably a likely cause for the observed in vivo effects with respect to improved cognitive performance. These data suggest that ACD856 may have a beneficial effect on cognition in patients with cognitive dysfunction and the compound is currently in clinical development for the treatment of cognitive dysfunction in Alzheimer’s disease.