γ-8

2022-05-05: reference:

TARP γ8 (Transmembrane AMPAR regulatory protein) #

• Most abundantly expressed in the Hippocampus R, and perhaps the principal TARP afaik. Stargazin is still ubiquitous though.
• CaMKII phosphorylation of TARPgamma-8 is a mediator of LTP and learning and memory Knockout severely depletes LTP by means of reducing the pool of eAMPAR, which are indeed required. Maybe they’re actually neuroprotective compared to eNMDAR? Who knows.