α6 nAChR

2023-12-19:

α6 nAChR #

• M: I looked at it now. Phenylpiracetam might also be less addictive since it might not have affinity for a6 type nachrs. Both a4 and a6 types are potent dopamine releaser
• S: in what i posted i decided was true after reading a fuck ton of similar papers. looks like it upregulates trka and enhances ngf binding, which upregulates nicotinic receptors, and ligands get trapped in nicotinic receptors which causes depressed activity
• M: *Thats possible but a6 nachrs downregulate, a4a5b2 are resistant so TrkA binding might only affect subset of interneurons thats close to nachrs that released NGF *