α2δ

2023-01-05:

α2δ #

• One gene forming two subunits (linked via disulfide bond) of VGCC.
• Gabapentin/pregabalin disrupts it. This prevents calcium channel membrane delivery to cell membrane, and disrupts α2δ interactions with NMDAR, neurexins, and Thrombospondins.
  • Gabapentin has similar affinity to α2δ-1 and α2δ-2, the former being its principal MOA.
• Leucine/isoleucine are ligands that compete for binding with drugs