Enhancing consciousness = meaning of life

How to absorb information

Belighting one brilliant benzhydryl

Transhumanist musings

There is amyloidogenic processing, and nonamyloidogenic. The former is regulated by BACE1, the latter is α-secretase, which cleaves the dangerous stub (Forming the α-CTF (C-terminal fragment), or the APP intracellular domain (AICD)). Notice the fully intramembrane α-secretase. Real? Can’t be. Look at the cleavage site. Truncated and modified amyloid-beta species Note how there’s a possible BACE1→ADAM10 route. More fun is how there are other secretases like η and γ. APP exists in several isoforms ranging from 695 to 770 amino acids in length, including the domain from which the Aβ peptide derives Not just amyloid: physiological functions of the amyloid precursor protein family (Müller 2017) (Highly detailed, especially noncanonical δ/η stuff....